Our keynote speaker, Professor Yamamoto and his research team have developed an innovative strategy termed PITCh (Precise Integration into Target Chromosome), for gene knock-in using TALENs and CRISPR/ Cas9-mediated by microhomology-mediated end-joining (MMEJ). TALEN-mediated PITCh was demonstrated to be able to integrate exogenous donor DNA into target sites on chromosomes in human cells, silkworms, and frogs, while the CRISPR/Cas9-mediated PITCh was successfully applied in human cells and mice without carrying the plasmid backbone sequence. Professor Yamamoto will be sharing with us his findings and insights on genome editing during the FGSB 2018.
Nakade et al. (2014) Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9. Nature Communications 5: 5560 DOI: 10.1038/ncomms6560.
Sakuma et al. (2016) MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems. Nat Protoc. 11:118-133. DOI: 10.1038/nprot.2015.140.
Professor Edwards‘s research focus is on crop plant genomics. His current research activities include the characterization of complex plant genomes, translational genomics and genome informatics, with a focus on wheat, Brassica and chickpea crops. Prof. Edwards have published in many peer reviewed journals such as Science, Nature Genetics, Nature Biotechnology, Nature Communications and Genome Biology. Professor Edwards will share his research findings and experience with us on plant functional genomics during the FGSB 2018.
Dr. Mohd Firdaus’s research interests include: (i) the structure and function of non-coding RNA molecules and how their interactions with other macromolecules effect regulatory changes in the cell, (ii) the structure, function and evolution of proteins with currently uncharacterized functions (hypothetical proteins) and (iii) additional layers of information encoded within the genome such as methylation and small hypothetical proteins (sORFs).
Dr. Mohd Firdaus will share his research findings and experience with us on structural biology during the FGSB 2018.
Dr. Vongsangnak obtained her PhD in Bioscience from the Chalmers University of Technology, Gothenburg, Sweden. She joined Soochow University as an Associate Professor at the Center for Systems Biology in 2011. Presently, she is an Associate Professor in the Faculty of Science, Kasetsart University. She is also a leader of Bioinformatics and Systems Biology Unit (BSBU), Computational Biomodelling Laboratory for Agricultural Science and Technology (CBLAST).
Her research Interests include: (i) bioinformatics techniques and analysis, (ii) comparative genomics and transcriptomics analysis, (iii) multilevel-omics data analysis and integrations and (iv) biological networks analysis.
Dr. Vongsangnak will share her research findings and experience with us on “Fungal systems biology to uncover the network of life” during the FGSB 2018.
Professor Higuchi‘s field of expertise is in structural biology and protein crystallography. His research interests are on proteins in energy metabolism (especially hydrogenases) and in signal transduction. Prof. Higuchi has published in many peer reviewed journals such as Science, Nature, Nat Struct Mol Biol, Proc Natl Acad Sci USA and J Biol Chem.
Professor Higuchi will share his research findings and experience with us on the comprehensive structural chemistry of [NiFe]-hydrogenases during the FGSB 2018.
Plenary speaker (Cancer Transcriptomics)
Professor Dr. Abhimanyu Veerakumarasivam
Sunway Institute for Healthcare Development, Sunway University, Malaysia
Professor Veerakumarasivam‘s research in cancer genetics involves the elucidation of components of the regulatory pathways that drive tumour recurrence and invasion as well as dissecting Asian genetic variations that confer differences in disease-risk and response to therapy. He received his doctorate from the University of Cambridge. Before joining Sunway University, he served at Universiti Putra Malaysia and Perdana University. In recognition of his achievements, he has been awarded multiple awards including the National Cancer Council Malaysia Cancer Research Award and the Merdeka Award Grant. He was crowned the Best Science Communicator at the 2016 International Famelab Finals in the UK. He is currently the Chairman of the Young Scientists Network-Academy of Sciences Malaysia (YSN-ASM). He is also currently the Chair of the International Network for Government Science Advice Asia Steering Committee and a member of the Global Young Academy.
Invited speaker (Evolutionary Genomics and Comparative Phylogenomics)
Dr. Cheng obtained his PhD in in genomics and bioinformatics from The University of Hong Kong in 2016. He has joined BGI-Shenzhen since 2008, and has ample of experience working on plant-omics research and bioinformatics, with a particular research interest in comparative and evolutionary genomics.
He has also participated in many international genomics consortia such as the Giant Panda Genomics Project, the International Potato Genome, Tomato genome, Brassica rapa Genome, and Carrot Genome. He also led the genome projects of Foxtail millet, Symbiodinium and Cleome that have been published in top-tier journals. His current focus is on the genome evolution and diversity of root nodule symbiosis, and comparative phylogenomics study of a broad phylogenetic diversity of all green plants, especially the 10KP effort.